Unraveling the Structure of Viral Replication Complexes at Super-Resolution
Identifieur interne : 000A74 ( Main/Exploration ); précédent : 000A73; suivant : 000A75Unraveling the Structure of Viral Replication Complexes at Super-Resolution
Auteurs : Olga Linnik [Royaume-Uni] ; Johannes Liesche [Danemark] ; Jens Tilsner [Royaume-Uni] ; Karl J. Oparka [Royaume-Uni]Source :
- Frontiers in Plant Science [ 1664-462X ] ; 2013.
Abstract
During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed “X-bodies,” as their function was not immediately appreciated. Whilst some inclusion bodies may represent cytopathic by-products of viral protein over-accumulation, X-bodies have emerged as virus “factories,” quasi-organelles that coordinate diverse viral infection processes such as replication, protein expression, evasion of host defenses, virion assembly, and intercellular transport. Accordingly, they are now generally referred to as viral replication complexes (VRCs). We previously used confocal fluorescence microscopy to unravel the complex structure of X-bodies produced by Potato virus X (PVX). Here we used 3D-structured illumination (3D-SIM) super-resolution microscopy to map the PVX X-body at a finer scale. We identify a previously unrecognized membrane structure induced by the PVX “triple gene block” (TGB) proteins, providing new insights into the complex interplay between virus and host within the X-body.
Url:
DOI: 10.3389/fpls.2013.00006
PubMed: 23386855
PubMed Central: 3560349
Affiliations:
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Oparka</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Plant Sciences, University of Edinburgh</institution><country>Edinburgh, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division ofOral Biology, College ofDentistry, The Ohio State University, Columbus, OH 43210</wicri:regionArea><wicri:noRegion>OH 43210</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Plant Science</title><idno type="eISSN">1664-462X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed “X-bodies,” as their function was not immediately appreciated. Whilst some inclusion bodies may represent cytopathic by-products of viral protein over-accumulation, X-bodies have emerged as virus “factories,” quasi-organelles that coordinate diverse viral infection processes such as replication, protein expression, evasion of host defenses, virion assembly, and intercellular transport. Accordingly, they are now generally referred to as viral replication complexes (VRCs). We previously used confocal fluorescence microscopy to unravel the complex structure of X-bodies produced by Potato virus X (PVX). Here we used 3D-structured illumination (3D-SIM) super-resolution microscopy to map the PVX X-body at a finer scale. We identify a previously unrecognized membrane structure induced by the PVX “triple gene block” (TGB) proteins, providing new insights into the complex interplay between virus and host within the X-body.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, M J" uniqKey="Adams M">M. J. Adams</name></author><author><name sortKey="Antoniw, J F" uniqKey="Antoniw J">J. F. Antoniw</name></author><author><name sortKey="Bar Joseph, M" uniqKey="Bar Joseph M">M. Bar-Joseph</name></author><author><name sortKey="Brunt, A A" uniqKey="Brunt A">A. A. Brunt</name></author><author><name sortKey="Candresse, T" uniqKey="Candresse T">T. Candresse</name></author><author><name sortKey="Foster, G D" uniqKey="Foster G">G. D. Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allison, A V" uniqKey="Allison A">A. V. Allison</name></author><author><name sortKey="Shalla, T A" uniqKey="Shalla T">T. A. 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Oparka</name><name sortKey="Tilsner, Jens" sort="Tilsner, Jens" uniqKey="Tilsner J" first="Jens" last="Tilsner">Jens Tilsner</name><name sortKey="Tilsner, Jens" sort="Tilsner, Jens" uniqKey="Tilsner J" first="Jens" last="Tilsner">Jens Tilsner</name></country><country name="Danemark"><noRegion><name sortKey="Liesche, Johannes" sort="Liesche, Johannes" uniqKey="Liesche J" first="Johannes" last="Liesche">Johannes Liesche</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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